Pakalipano, pali mitundu pafupifupi 81 ya mankhwala oletsa chotupa omwe amagwiritsidwa ntchito kwambiri pachipatala.1. Mankhwala a anti-chotupa amagawidwa molingana ndi gwero lawo komanso momwe amagwirira ntchito.Nthawi zambiri anawagawa alkylating mankhwala, antimetabolites, mankhwala, zomera, mahomoni ndi mankhwala ena.Mankhwala ena ndi monga platinamu, asparaginase, mankhwala ochizira omwe akuwongolera, ndi zina zotere, kupatula zopangira zamoyo ndi mankhwala a jini.Gulu ili silingafotokoze mwachidule chitukuko chamakono cha mankhwala odana ndi chotupa.Chachiwiri, gulu lina limachokera ku zolinga za maselo a mankhwala, omwe amagawidwa m'magulu ambiri.Gulu loyamba ndi mankhwala omwe amagwira ntchito pamakina a DNA, monga alkylating kapena platinamu.Gulu lachiwiri ndi mankhwala omwe amakhudza kaphatikizidwe ka nucleic acid, monga antimetabolites.Gulu lachitatu ndi mankhwala omwe amagwira ntchito pa template ya DNA, amakhudza kulembedwa ndi kuletsa kwa DNA, ndipo amalepheretsa kaphatikizidwe ka RNA podalira RNA polymerase.Gulu lachinayi ndi mankhwala omwe amakhudza kaphatikizidwe ka mapuloteni, monga paclitaxel, vinblastine ndi zina zotero.Gulu lomaliza ndi mitundu ina yamankhwala, monga mahomoni, aspartic acid, mankhwala ochizira, ndi zina zotero, koma mankhwala omwe alipo odana ndi chotupa akukula mofulumira, ndipo magulu omwe ali pamwambawa sangathe kufotokoza mwachidule mankhwala omwe alipo ndi mankhwala omwe ali pafupi. kulowa kuchipatala..“

Pakali pano, pali mankhwala ambiri odana ndi chotupa m'chipatala.Mwachitsanzo,oxaliplatin, mankhwala fluorouracil, ndi irinotecan angagwiritsidwe ntchito zotupa m'mimba.Odwala khansa ya m'mimba amatha kuthandizidwa ndi mankhwala mongacisplatinndipaclitaxel.Nthawi zambiri, khansa zosiyanasiyana zimasankha mankhwala osiyanasiyana.Kuphatikiza apo, odwala khansa amathanso kuthandizidwa ndi mankhwala omwe amapangidwa ndi maselo, monga erlotinib, osimertinib, cetuximab ndi mankhwala ena.

Mankhwala odana ndi chotupa omwe amayambitsa CIPN akuphatikizapoPaclitaxel, Platinum, Vinblastine,MethotrexateFluorouracil, Ifosfamide,CytarabineFludarabine, Thalidomide,Bortimiazolendi zina zotero.

Paclitaxel amagwiritsa ntchito kukula kwa minyewa kuti achepetse kapena kubweza neurotoxicity;cisplatin imagwiritsa ntchito glutathione yochepetsedwa ndi amifostine kuti ateteze matenda a neuropathy omwe amayamba chifukwa cha izi;oxaliplatin samakhudzana ndi kukondoweza kuzizira pakagwiritsidwe ntchito kuti tipewe kukondoweza kuzizira kuti zisakhudze zotumphukira misempha Kukondoweza, kugwiritsa ntchito osakaniza a calcium-magnesium kumatha kuchepetsa kuchuluka kwa zizindikiro za neurotoxicity pachimake, ndikuchedwetsa kuyambika kwa neuropathy;ifosfamide amatha kusankha methylene buluu kuti ateteze neurotoxicity;kugwiritsa ntchito thiamine kwa fluorouracil kungalepheretse misempha.